Ureaplasma urealyticum, in most cases, is easy to treat. Because Ureaplasma urealyticum lacks a cell wall, it is not susceptible to penicillins or cephalosporins – which works by disrupting the synthesis of the peptidoglycan layer of a bacteria’s cell wall.

Currently, the initial recommended therapy prescribed by physicians is:

  • Doxycycline 100 mg twice daily for 2 weeks; or
  • a single dose of Azithromycin (1000 mg orally) which can be repeated in 10-14 days

Doxycycline is the drug of choice. Other alternatives include Erythromycin, Ofloxacin and Minocycline.

If the infection is left untreated, it can spread to the central nervous system or joints. Some people are resistant to some types of antibiotics for Ureaplasma urealyticum. If the condition is still present after the initial treatment, a different type of antibiotic may be prescribed by the physician.

When both sexual partners show signs of Ureaplasma urealyticum, they should be taking antibiotics simultaneously as prescribed by the physician. Safe sex should be implemented by both partners until treatment is finished. A repeat culture (test) should be taken after treatment to ensure the infection was eradicated.



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